From Diagnosis to Intervention: Nurses’ Role in Managing TA-TMA at the Bedside

Presenter: Sonata Jodele, MD

This session examines transplant-associated thrombotic microangiopathy (TA-TMA) as a significant complication of hematopoietic stem cell transplantation. Participants will gain an in-depth understanding of endothelial injury, disease pathophysiology, diagnostic criteria, and risk stratification.

The presentation emphasizes early recognition through clinical assessment, laboratory monitoring, and bedside observation. The critical role of nurses in detecting subtle clinical changes, managing hypertension, monitoring transfusion needs, and supporting multidisciplinary interventions is explored.

Learning Objectives:

Upon completion of this activity, participants will be able to:

• Define transplant-associated thrombotic microangiopathy and its pathophysiology
• Identify risk factors and early clinical indicators of TA-TMA
• Apply current diagnostic and risk stratification criteria
• Describe nursing responsibilities in monitoring and reporting disease progression
• Support early intervention strategies to reduce morbidity and mortality

Target Audience: Transplant nurses, oncology nurses, advanced practice providers, and clinicians involved in stem cell transplantation care.